Cytogenetics / FISH
Karyotype
Karyotyping, or chromosomal analysis, can provide insights into diagnosis, prognosis, and prediction of disease in many acute and chronic leukemias and lymphomas. Traditional G-banding for metaphase analysis with specific cell culturing and read out by two independent cytotechnologists ensures optimal results.
- Best-in-industry turnaround time (3 days)
- Cell-specific culture (myeloid, B-cell, T-cell)
- <1% culture failure*
FISH
With its ability to bind to only specific parts of a chromosome and spotlight abnormalities through their tagged fluorescence on cells when viewed under a fluorescence microscope, fluorescence in situ hybridization (FISH, also known as molecular cytogenetics), can identify abnormalities that may be missed at a macro level in karyotype, but can captured on a micro level in FISH.
- Best-in-industry turnaround time (2 days)
- Disease-focused panels for myeloid, lymphoid, and plasmacytic disorders including cell enrichment
- Complete suite of hematopoietic FISH probes for custom panels and follow up
- HER2, ALK, ROS1, MET, RET, 1p/19q, PTEN and UroVysion for solid tumor analysis
| Karyotyping for myeloid/lymphoid disorders | Notes |
|---|---|
| Chromosome Analysis, Bone Marrow and Peripheral Blood, UNSTIMULATED | Myeloid 24 and 48 hour cultures |
| Chromosome Analysis, Bone Marrow, STIMULATED (T- and B-Cell, Lymphoproliferative Disorders, Plasma Cell) |
T-Cell 72 hour culture, if necessary B-Cell 120 hour culture, if necessary |
| Chromosome Analysis, Blood UNSTIMLUATED | Myeloid 24 and 48 hour cultures |
| Chromosome Analysis, Blood
STIMULATED (T- and B-Cell, Lymphoproliferative Disorders, Plasma Cell) |
T-Cell 72 hour culture, if necessary B-Cell 120 hour culture, if necessary |
*With appropriate cell-specific culture, karyotype, and FISH triage.
| Hematologic FISH Panels and Probes | |||
|---|---|---|---|
| ALL FISH Panel |
|
Mantle Cell Lymphoma FISH | CCND1/IGH t(11;14) |
| AML FISH Panel |
|
Marginal Zone / MALT Lymphoma FISH Panel |
|
| Burkitt’s Lymphoma FISH Panel |
|
MDS FISH Panel |
|
| CLL FISH Panel |
|
MPN FISH Panel |
|
| CML FISH | BCR/ABL t(9;22) | Myeloma FISH Panel |
|
| Eosinophilia FISH Panel |
|
Myeloma FISH Reflex panel |
|
| Follicular Lymphoma FISH Panel |
|
||
All FISH probes are available individually or in custom panels.
| Solid Tumor FISH Panels and Probes | |||
|---|---|---|---|
| NSCLC FISH Panel |
|
UroVysion Bladder FISH Panel |
|
| HER2 FISH |
|
|
|
All FISH probes are available individually or in custom panels.
"While we have many laboratories to choose from, we consider siParadigm to be the most reliable. Contact with a hematopatholgist is rapid and informative."
Barry Kaplan, MD, PhD
Oncologist/Hematologist, Queens Medical Assoc.
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