The benefit of being able to amplify, and in some instances, quantitate, copies of DNA through PCR, has yet to be displaced for its value in providing rapid and sensitive identification of single nucleotide polymorphisms (SNPs) and specific gene translocations.
Analysis | Reflex Options / Notes |
---|---|
ABL Kinase Domain Mutation Analysis (T315I) | |
B-Cell Gene Rearrangement (IGH) | |
BCR/ABL1 – Major (p210) AND Minor (p190) QUALITATIVE | |
BCR/ABL1 – Major (p210) AND Minor (p190) QUANTITATIVE | |
BCR/ABL1 – Major (p210) QUANTITATIVE | Reporting according to International Scale (IS) Reflex to ABL Kinase Domain Mutation Analysis |
BCR/ABL1 – Minor (p190) QUANTITATIVE | |
CALR Mutation Analysis | Available in MPN NGS Panel |
CEBPA Mutation Analysis | Available in AML or Pan-Myeloid NGS Panels |
FLT3-ITD | Available in AML or Pan-Myeloid NGS Panels |
IgHV Mutation Analysis | |
JAK2 V617F Mutation Analysis | Reflex to JAK2 Exon 12 Mutation Analysis Reflex to MPL and CALR Mutation Analysis Available in MPN NGS Panel |
JAK2 Exon 12 Mutation Analysis | Available in MPN NGS Panel |
KIT (c-KIT) Mutation Analysis (Exons 8 and 17) | |
KIT (c-KIT) Mutation Analysis (D816) | |
MPL W515 K/L Mutation Analysis | Available in MPN NGS Panel |
NPM1 Mutation Analysis | Available in AML or Pan-Myeloid NGS Panels |
T-Cell Gene Rearrangement (Beta/Gamma) |
Desiree A. Carlson, MD
Chief of Pathology, Signature Healthcare
With core values rooted in service and integrity, our leadership team sets the bar high.
We consistently strive to set the model for exactly how a reference laboratory should engage with both physicians and patients.
siParadigm is accredited by CLIA (Clinical Laboratory Improvement Amendments) and certified by CAP (College of American Pathologists).
We also hold select state licensure where required.